Molecular analysis of drug resistant TB

Management of Drug-Resistant TB

Multidrug resistant TB and extensively drug resistant TB

Resistance to anti-TB drugs is not an emerging phenomenon, but a process closely related to the implementation of chemotherapy against TB. Clinical evidence to prove the development of resistance to anti-TB drugs was provided by the Medical Research Council team in 1948, shortly after using streptomycin in (as?) monotherapy for TB treatments 1. As isoniazid, PAS and streptomycin were first used...

Molecular Analysis and Expression of bap Gene in Biofilm-Forming Multi-Drug-Resistant Acinetobacter baumannii

Background: Acinetobacter baumannii is commonly resistant to nearly all antibiotics due to presence of antibiotic resistance genes and biofilm formation. In this study we determined the presence of certain antibiotic-resistance genes associated with biofilm production and the influence of low iron concentration on expression of the biofilm-associated protein gene (bap) in development of biofilm...

Molecular Approaches for Detection of the Multi-Drug Resistant Tuberculosis (MDR-TB) in Bangladesh

The principal obstacles in the treatment of tuberculosis (TB) are delayed and inaccurate diagnosis which often leads to the onset of the drug resistant TB cases. To avail the appropriate treatment of the patients and to hinder the transmission of drug-resistant TB, accurate and rapid detection of resistant isolates is critical. Present study was designed to demonstrate the efficacy of molecular...

World TB Day 2018: The Challenge of Drug Resistant Tuberculosis

On 24th March, the world commemorates the day in 1882 when Dr Robert Koch announced his discovery of Mycobacterium tuberculosis (MTB). Over 130 years later, tuberculosis (TB) continues to affect individuals, communities, and entire health systems and economies. Koch unsuccessfully tried to 'cure' TB, and despite major advances in other areas of medicine, control of TB remains elusive- in 2016 T...